As regenerative technologies continue to reshape implant dentistry, clinicians have more tools than ever to improve bone quality, simplify treatment, and support long-term implant success. Among the most promising advances are biologic materials designed to harness the body’s natural healing mechanisms and create more predictable regenerative outcomes.
For George A. Mandelaris, DDS, MS, these innovations represent the latest chapter in a career dedicated to advancing implant therapy through evidence-based diagnosis and treatment planning. “The field has exponentially changed since I started,” says the Illinois-based practitioner. “Imaging and all the improvements centered around diagnostics have been the most influential aspects that have improved diagnosis and interdisciplinary treatment planning for the betterment of patient care.”
Coming in a close second as a key advancement, he notes: the evolution of biologics and growth factor technologies. “These have helped make regenerative procedures more predictable while expanding treatment options for patients requiring bone reconstruction before implant placement.”
One biologic that has become an integral part of Mandelaris’ regenerative protocol is INDUCE Oi-9® from Induce Biologics. He uses INDUCE Oi-9 in a variety of procedures, including socket preservation and reconstruction, guided bone regeneration, guided periodontal regeneration, peri-implantitis management, and bone morphotype modification during surgically facilitated orthodontic therapy.
“I have had a very positive experience with INDUCE Oi-9,” he affirms. “The outcomes have been quite favorable in terms of regeneration where, upon re-entry, the results appear like native bone.”
According to Mandelaris, the product’s proprietary NMP® (Natural Matrix Protein®) processing protocol distinguishes it from conventional demineralized bone allografts by making multiple native growth factors—including bone morphogenetic proteins—more bioavailable. From his clinical perspective, this translates into improved bone quality and quantity while avoiding the significant postoperative edema sometimes associated with products that rely on a single recombinant growth factor. The material’s handling characteristics are another advantage, he says, noting that INDUCE Oi-9 is easy to use across a broad range of regenerative procedures.
“The key for any bone graft operation,” Mandelaris suggests, “is obtaining a regenerated functional matrix capable of withstanding stress/strain and that responds favorably to mechanical loading. A living, vascularized functional matrix construct should result in sustainability within the host long-term. INDUCE Oi-9 appears to produce excellent bone regeneration from a clinical standpoint.”
Beyond its clinical performance, Mandelaris appreciates that INDUCE Oi-9 conveniently stores at room temperature, has a 5-year shelf-life, and helps streamline inventory by serving as a versatile regenerative bioimplant suitable for numerous clinical indications.
For Mandelaris, innovations like INDUCE Oi-9 reflect the continued evolution of regenerative dentistry. “It is exciting to see how INDUCE Oi-9 has combined basic science with optimizing the human capacity of wound healing—harnessing biologics to restore health and function. The regeneration era is becoming more predictable through breakthroughs such as INDUCE Oi-9.”
George A. Mandelaris, DDS, MS
Private Practice limited to Periodontology, Dental Implant Surgery, Bone Reconstruction, and Tissue Engineering Surgery, Glenview and Oakbrook Terrace, Illinois; Fellow, American College of Dentists and International College of Dentists
Induce Biologics
888-864-4906
inducebiologics.com
